The season follows the story of surgical interns, residents and their competent mentors, as they experience the difficulties of the competitive careers they have chosen. It is set in the surgical wing of the fictional Seattle Grace Hospital, located in Seattle, Washington. A major storyline of the season is the characters adapting to change, as their beloved co-worker Stevens departed following the breakdown of her marriage, O’Malley died in the season premiere—following his being dragged by a bus, and new cardiothoracic surgeon Teddy Altman is given employment at the hospital. Further storylines include Shepherd being promoted to chief of surgery, Seattle Grace Hospital merging with the neighboring Mercy West —introducing several new doctors, and several physicians lives being placed into danger—when a grieving deceased patient’s husband embarks on a shooting spree at the hospital, seeking revenge for his wife’s death.
- 6 - 1Good Mourning 24. Sep, 2009
- 6 - 2Goodbye 24. Sep, 2009
- 6 - 3I Always Feel Like Somebody's Watchin' Me 01. Oct, 2009
- 6 - 4Tainted Obligation 08. Oct, 2009
- 6 - 5Invasion 15. Oct, 2009
- 6 - 6I Saw What I Saw 22. Oct, 2009
- 6 - 7Give Peace a Chance 29. Oct, 2009
- 6 - 8Invest In Love 05. Nov, 2009
- 6 - 9New History 12. Nov, 2009
- 6 - 10Holidaze 19. Nov, 2009
- 6 - 11Blink 14. Jan, 2010
- 6 - 12I Like You So Much Better When You're Naked 21. Jan, 2010
- 6 - 13State of Love and Trust 04. Feb, 2010
- 6 - 14Valentine's Day Massacre 11. Feb, 2010
- 6 - 15The Time Warp 18. Feb, 2010
- 6 - 16Perfect Little Accident 04. Mar, 2010
- 6 - 17Push 11. Mar, 2010
- 6 - 18Suicide is Painless 25. Mar, 2010
- 6 - 19Sympathy for the Parents 01. Apr, 2010
- 6 - 20Hook, Line and Sinner 29. Apr, 2010
- 6 - 21How Insensitive 06. May, 2010
- 6 - 22Shiny Happy People 13. May, 2010
- 6 - 23Sanctuary 20. May, 2010
- 6 - 24Death and All His Friends 20. May, 2010